AINeutralarXiv – CS AI · 9h ago6/10
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Learning Multi-Relational Graph Representations for DNA Methylation-Based Biological Age Estimation
Researchers introduce RelAge-GNN, a graph neural network framework that models complex biological relationships among DNA methylation sites to improve aging clock predictions. The method outperforms existing approaches in estimating biological age and shows enhanced sensitivity for detecting age acceleration in disease cohorts, with interpretability analysis revealing which relationships and CpG sites drive predictions.