The MAMA-MIA Challenge: Advancing Generalizability and Fairness in Breast MRI Tumor Segmentation and Treatment Response Prediction

The MAMA-MIA Challenge introduced a large-scale benchmark for AI-powered breast cancer tumor segmentation and treatment response prediction using MRI data from 1,506 US patients for training and 574 European patients for testing. Results from 26 international teams revealed significant performance variability and trade-offs between accuracy and fairness across demographic subgroups when AI models were tested across different institutions and continents.