AINeutralarXiv – CS AI · 4h ago5/10
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Stable-Shift: Biologically Structured Prediction of Transcriptional Responses to Unseen Gene Perturbations
Stable-Shift introduces a structured machine learning method for predicting how genes respond to perturbations without requiring experimental data from those genes. The approach outperforms existing methods like GEARS on benchmark datasets, achieving 0.592 cosine similarity, and demonstrates the value of integrating biological context through graph neural networks for genomic prediction tasks.