Identifying and Characterising Response in Clinical Trials: Development and Validation of a Machine Learning Approach in Colorectal Cancer

Researchers developed a machine learning approach combining Virtual Twins method with survLIME to identify patient subgroups who respond differently to treatments in clinical trials. The method achieved 0.77 AUC for identifying treatment responders in colorectal cancer trials, finding genetic mutations, metastasis sites, and ethnicity as key response factors.