AIBullisharXiv – CS AI · 4h ago6/10
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Privacy-preserving federated tensor decomposition of single-cell immune data: recovering multicellular programs across institutions
Researchers developed a federated tensor decomposition method that enables privacy-preserving analysis of single-cell immune data across multiple institutions without sharing raw patient data. The approach recovers multicellular immune programs—coordinated patterns of gene expression across cell types—while protecting patient privacy through secure aggregation, demonstrated on systemic lupus erythematosus and COVID-19 datasets.