AINeutralarXiv – CS AI · 7h ago6/10
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FreeBridge: Variational Schr\"odinger Bridges for Cellular Transition Dynamics
FreeBridge, a new computational method based on Schrödinger Bridges, addresses a fundamental challenge in cellular biology by inferring continuous cell transition pathways from static snapshots. The approach constrains predicted intermediate cell states to geometrically valid regions observed in real data, improving both accuracy and biological interpretability in perturbation modeling across multiple imaging datasets.