AINeutralarXiv – CS AI · 10h ago6/10
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Learning the Interaction Prior for Protein-Protein Interaction Prediction: A Model-Agnostic Approach
Researchers propose L3-PPI, a biologically-informed machine learning approach for predicting protein-protein interactions by leveraging the L3 rule—the principle that multiple length-3 paths between proteins indicate interaction likelihood. The method integrates a lightweight graph prompt learning module into existing PPI predictors as a plug-and-play component, demonstrating superior performance over conventional approaches that rely on generic aggregation methods.