AINeutralarXiv – CS AI · 5d ago5/103
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General Protein Pretraining or Domain-Specific Designs? Benchmarking Protein Modeling on Realistic Applications
Researchers introduce Protap, a comprehensive benchmark comparing protein modeling approaches across realistic applications. The study finds that large-scale pretrained models often underperform supervised encoders on small datasets, while structural information and domain-specific biological knowledge can enhance specialized protein tasks.