AIBullisharXiv – CS AI · 15h ago7/10
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Co-folding model guided by structural proteomics
Researchers introduce AIMS-Fold, a guided-diffusion framework that integrates structural proteomics data (XL-MS and HDX-MS measurements) with protein structure prediction models to improve accuracy in predicting protein complex conformations. The approach outperforms unguided computational models on challenging induced proximity drug targets, advancing structure-based drug design capabilities.