AINeutralarXiv – CS AI · 10h ago6/10
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Chem2Gen-Bench: Benchmarking Chemical-to-Genetic Translation in Perturbation Response Space
Researchers introduce Chem2Gen-Bench, a comprehensive benchmark dataset containing over 1.3 million chemical and genetic perturbation profiles designed to evaluate how accurately computational models can translate chemical perturbations into genetic responses. The study reveals that while translation between these perturbation types is measurable, it remains heterogeneous across different cellular contexts, and current foundation-model embeddings don't consistently outperform simpler baseline approaches.