AINeutralarXiv – CS AI · 7h ago6/10
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GC-MoE: Genomics-Guided Cell-Type-Specific Mixture of Experts for Histology-Based Single-Cell Spatial Transcriptomics
Researchers introduce GC-MoE, a machine learning framework that predicts individual cell gene expression from histopathology images and spatial data, addressing limitations of existing methods that only work at the spot level. The approach combines cell-type-specific expert models with genomic guidance to capture cellular expression variability more accurately than current baselines.